References Inositol

References and research citations

Each structure and function claim on this page is anchored to peer-reviewed research retrieved from PubMed, organized by theme. Citation framing here is descriptive of the underlying science. It does not represent claims that Inositol diagnoses, treats, cures, or prevents any disease.

Myo-inositol and d-chiro-inositol, the body's two inositols

Myo-inositol and d-chiro-inositol are two naturally occurring forms of inositol. Both act as second messengers inside cells, part of the everyday signaling the body relies on.*

  1. Strålfors P. 1997. BioEssays. 19(4): 327 to 335. PMID 9136630.
  2. Dinicola S, Unfer V, Facchinetti F, et al. 2021. International Journal of Molecular Sciences. 22(19): 10575. PMID 34638926.

The 40 to 1 ratio of myo-inositol to d-chiro-inositol

Body tissues hold myo-inositol and d-chiro-inositol in a specific balance. The 40 to 1 ratio reflects the balance described across the published research on inositol.*

  1. Monastra G, Unfer V, Harrath AH, Bizzarri M. 2016. Gynecological Endocrinology. 33(1): 1 to 9. PMID 27898267.
  2. Pizzo A, Laganà AS, Barbaro L. 2014. Gynecological Endocrinology. 30(3): 205 to 208. PMID 24351072.

Myo-inositol, d-chiro-inositol, and cycle rhythm

Daily myo-inositol and d-chiro-inositol are part of a structure and function approach to supporting a steady monthly cycle rhythm.*

  1. Kachhawa G, Senthil Kumar KV, Kulshrestha V, et al. 2021. International Journal of Gynaecology and Obstetrics. 158(2): 278 to 284. PMID 34624138.
  2. Greff D, Juhász AE, Váncsa S, et al. 2023. Reproductive Biology and Endocrinology. 21(1): 10. PMID 36703143.

Hormonal coordination month to month

Myo-inositol and d-chiro-inositol support the body's natural hormonal coordination across the monthly cycle.*

  1. Gul M, Khan H, Rauf B, et al. 2025. Naunyn-Schmiedeberg's Archives of Pharmacology. 398(7): 8761 to 8772. PMID 39847053.
  2. Bhide P, Pundir J, Gudi A, et al. 2019. Acta Obstetricia et Gynecologica Scandinavica. 98(10): 1235 to 1244. PMID 30993683.

Emotional balance across the cycle

Myo-inositol acts as one of the body's second messengers, part of how it supports steady mood and emotional balance across the month.*

  1. Carlomagno G, Unfer V, Buffo S, D'Ambrosio F. 2011. Human Psychopharmacology. 26(7): 526 to 530. PMID 22031267.

Studied compounds, formulated for daily use

Myo-inositol and d-chiro-inositol are among the most studied compounds in women's wellness and are formulated here for daily, long-term use.*

  1. Placidi M, Casoli G, Tatone C, Di Emidio G, Bevilacqua A. 2024. Biology. 13(11): 936. PMID 39596891.
  2. Unfer V, Porcaro G. 2014. Expert Review of Clinical Pharmacology. 7(5): 623 to 631. PMID 24898153.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Consult your healthcare provider before starting any new supplement, especially if you are pregnant, nursing, taking prescription medication, or managing a health condition. All citations sourced from PubMed.